• Home
  • About Us
    • Our Story
    • What is Hereditary Cancer
    • Hereditary Cancer Types
    • Risk Factors
    • Questions for Doctor
  • Programs
    • Test Positive. Now What?
    • Support Programs
    • Community Stories
    • Financial Resources
    • Lift Chair Program
  • News & Events
    • News
    • Events
    • Cops vs Cancer Fun Run
  • Get Involved
    • Volunteer
    • Advocacy
    • Contact Us
  • Donate
  • More
    • Home
    • About Us
      • Our Story
      • What is Hereditary Cancer
      • Hereditary Cancer Types
      • Risk Factors
      • Questions for Doctor
    • Programs
      • Test Positive. Now What?
      • Support Programs
      • Community Stories
      • Financial Resources
      • Lift Chair Program
    • News & Events
      • News
      • Events
      • Cops vs Cancer Fun Run
    • Get Involved
      • Volunteer
      • Advocacy
      • Contact Us
    • Donate
  • Home
  • About Us
    • Our Story
    • What is Hereditary Cancer
    • Hereditary Cancer Types
    • Risk Factors
    • Questions for Doctor
  • Programs
    • Test Positive. Now What?
    • Support Programs
    • Community Stories
    • Financial Resources
    • Lift Chair Program
  • News & Events
    • News
    • Events
    • Cops vs Cancer Fun Run
  • Get Involved
    • Volunteer
    • Advocacy
    • Contact Us
  • Donate

Risk Factors

Navigating the complex world of cancer risk can be overwhelming. However, understanding hereditary cancer risk factors is a crucial step for individuals and families to take proactive measures. 


This guide will walk you through key concepts related to hereditary cancers, emphasizing the importance of genetic testing, and providing an assessment to help you understand your risk level.

Understanding Hereditary Cancer

Hereditary cancers account for about 10% of cancer cases, affecting men and women alike. These cancers are often the result of gene mutations passed from parent to child, though they can occasionally occur as new ("de novo") mutations

. 

Most hereditary cancer mutations are “autosomal dominant” in nature, meaning you only need one copy of the mutation to be high-risk for developing cancer. If a hereditary cancer mutation is present in your family, each first-degree relative has a 50% chance of inheriting it. Importantly, gene mutations do not skip generations. This means if you don’t have the mutation, your children won’t inherit it from you.

Key Terms

  • First-Degree Relatives: Parents, siblings, and children.
  • Second-Degree Relatives: Grandparents, aunts, uncles, and grandchildren.
  • Third-Degree Relatives: Great grandparents, great uncles/aunts, great grandchildren, and first cousins.

The Significance of Genetic Testing

Genetic testing is a powerful tool for assessing your risk of hereditary cancer. It provides insights into your genetic makeup, helping to identify genetic changes that could increase your cancer risk. Early awareness allows for life-saving actions, such as lifestyle modifications, enhanced screening plans, or preventive measures.

Recognizing Red Flags for Hereditary Cancer Syndromes

Understanding the patterns and signs that might indicate a hereditary cancer risk is crucial. Here’s what to look out for:

  • Multiple Cancers in one person or one side of the family.
  • Young Cancers diagnosed at age 49 or younger.
  • Rare Cancers such as male breast cancer or ovarian cancer.

Learn More

Take the Hereditary Cancer Risk Assessment

Assess your risk by answering the following questions. If you answer "yes" to any of these questions, consider consulting with a healthcare provider about genetic testing for hereditary cancer syndromes.

  • Do you have multiple family members who have been diagnosed with cancer?
  • Was any family member diagnosed with cancer before the age of 50?


  • Have you been diagnosed with cancer at a young age?
  • Have you had more than one type of cancer?


  • Has anyone in your family been diagnosed with rare cancers like male breast cancer?


  • Are there known genetic mutations in your family, such as BRCA1 or BRCA2?


  • Are you of Ashkenazi Jewish descent?


Understanding the Results and Next Steps

Once you decide to undergo genetic testing, understanding the results is the next empowering step in your health journey. Genetic testing may reveal three types of results: positive, negative, or “high risk negative”. 


Variants of uncertain significance (VUS) are common genetic changes included on genetic test reports, but at this time should not be used in medical management changes or health care decisions. Most laboratories offer family VUS studies you can participate in to help classify the VUS in your family. The vast majority of VUS are classified as “benign” or not disease causing. 


Discussing your results with a genetic counselor or healthcare provider ensures you fully comprehend your options and establishes a personalized plan that maximizes your health and well-being. Being informed is the first step towards harnessing control and taking proactive, positive action for your life.

Positive Result

Variant of Uncertain Significance (VUS)

Positive Result

Indicates that a genetic mutation associated with increased cancer risk is present. This information allows you to take proactive measures towards your health. You might opt for increased surveillance, preventative surgery, or lifestyle changes to mitigate your risk. Remember, knowledge is power, and having this information can help you make informed decisions for your future.

Negative Result

Variant of Uncertain Significance (VUS)

Positive Result

Suggests that no known genetic mutations linked to increased cancer risk were detected. While this might bring relief, it's still important to adhere to general cancer screening guidelines and maintain a healthy lifestyle. Keep in mind that a negative result doesn’t eliminate cancer risk entirely, as non-genetic factors and other family history could still play a role.

High-Risk Negative

Variant of Uncertain Significance (VUS)

Variant of Uncertain Significance (VUS)

You do not have a specific hereditary cancer mutation increasing your risk of cancer. However, due to your family history or other biological or lifestyle factors your risk is higher than the general population and medical management changes may be considered. Discuss these results with your health care provider. 

Variant of Uncertain Significance (VUS)

Variant of Uncertain Significance (VUS)

Variant of Uncertain Significance (VUS)

This means a change in the DNA was found, but its link to cancer risk is uncertain. Continued research may eventually clarify these findings. It’s crucial to discuss this with a healthcare professional who can guide you through the implications and any potential next steps.

Join Our Community

Being informed is empowering, but having support is crucial. By joining our community, you will gain access to:

  • Support Groups where you can share experiences and gain strength from others in similar situations.
  • Educational Resources to keep you informed about the latest in genetic testing and cancer prevention.
  • Expert Guidance from professionals who can assist you in making informed decisions.


Take control of your health today. Join our community for support and resources that will help you on your path to understanding and managing hereditary cancer risk.


Remember, knowing your risk means you can act upon it, possibly preventing cancer before it starts. Empower yourself with knowledge and take steps towards safeguarding your health and that of your loved ones.

Join Our Community

Support Programs

Genetic Testing Support

Genetic Testing Support

Genetic Testing Support

We provide financial assistance for genetic testing to individuals and families, ensuring they can access the necessary tools for early detection.

Learn More

Awareness and Education

Genetic Testing Support

Genetic Testing Support

Through campaigns and resources, we raise awareness about hereditary cancer risks and appropriate medical management for high-risk individuals and families.

Learn More

Support for High-Risk Individuals

Support for High-Risk Individuals

Support for High-Risk Individuals

We offer a platform of community support, online discussions, in-person groups, and educational seminars to empower those at risk.

Learn More

Research and Collaboration

Support for High-Risk Individuals

Support for High-Risk Individuals

Our members actively participate in and promote research studies, providing a bridge between patients and research opportunities.

Learn More

Get Involved

Get Involved

We invite you to join us on our mission. Together, we can transform lives through awareness, education, and support. Your contribution, whether through volunteering, donations, or partnerships, helps us move closer to a world where everyone knows their risk of hereditary cancer and can take appropriate action.


For more information on how you can get involved, please contact us. Let's make a difference together.

Drop us a line!

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

The Hereditary Cancer Foundation complies with applicable Federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex.


Copyright © 2024 Hereditary Cancer Foundation - All Rights Reserved. 

Powered by

This website uses cookies.

We use cookies to analyze website traffic and optimize your website experience. By accepting our use of cookies, your data will be aggregated with all other user data.

Accept