Hereditary cancers account for 10% of all cancer cases, affecting both men and women. These cancers arise from gene mutations passed down through generations, significantly increasing the risk for certain types of cancers. At the Hereditary Cancer Foundation, we're committed to supporting those at risk and providing vital information to healthcare professionals and at-risk individuals and families.
Knowing your hereditary cancer risk can be a game-changer. When individuals are aware of their increased risk, they can collaborate with healthcare providers to develop early detection and prevention strategies, ultimately saving lives. While inheriting a cancer-related genetic mutation doesn't guarantee cancer, it does mean a heightened risk. Understanding this risk is crucial for taking proactive measures.
Genes are the instructions for our body to grow and function properly. When changes or mutations occur in these genes, cells may not function as intended, leading to the development of cancer. Inheriting these gene mutations significantly increases the risk of developing certain types of cancers.
Genetic testing plays a pivotal role in identifying individuals at increased risk for hereditary cancers. It involves analyzing your DNA to look for specific mutations associated with a higher likelihood of developing cancer. Discovering these mutations can empower you to make informed decisions about your health and take preventive steps. Genetic testing is not just a tool for those with a family history of cancer; it can be beneficial for anyone who wants to understand their genetic predisposition.
By opting for genetic testing, you give yourself the opportunity to engage in proactive healthcare. With the guidance of healthcare providers and genetic counselors, test results can help craft personalized surveillance plans, such as regular screenings and lifestyle modifications, to manage cancer risk effectively. Additionally, sharing your genetic information with family members allows them to also assess their own risks and consider testing if necessary.
In a rapidly advancing field, being informed about genetic testing options and results interpretation is crucial. We are dedicated to providing you with comprehensive support throughout the genetic testing process, helping you navigate each step with confidence and clarity. Remember, empowered with knowledge, you can take steps toward a healthier future.
We raise awareness for various hereditary cancers, including: Breast Cancer, Ovarian Cancer, Pancreatic Cancer, Prostate Cancer, Colon Cancer, Gastric (Stomach) Cancer, Uterine (Endometrial) Cancer, Renal (Kidney) Cancer, Lung Cancer, Endocrine Cancers, Skin Cancers, Leukemia, Lymphoma
Hereditary breast cancer is commonly associated with mutations in the BRCA1 and BRCA2 genes. Knowing your BRCA status enables you to take proactive steps such as enhanced surveillance and considering risk-reducing measures. The aim is to detect any changes early, allowing for timely intervention.
Other mutations associated with an increased risk of breast cancer: TP53, PTEN, STK11, CDH1, PALB2, ATM, CHEK2, RAD51C, RAD51D, BARD1, NTHL1
With hereditary colon cancer, changes in several different genes, including those associated with Lynch syndrome, may be involved. Regular screening through colonoscopy is recommended, as it can help detect polyps before they develop into cancer. Embracing a lifestyle that incorporates a healthy diet and regular exercise can also serve as a preventative strategy, empowering you against this risk.
Lynch Syndrome Genes: MLH1, MSH2, MSH6, PMS2, EPCAM
Other genes associated with an increased risk of colorectal cancer: APC, MUTYH, TP53, PTEN, STK11, CHEK2, SMAD4, POLD1, POLE, GREM1, AXIN2, NTHL1, MSH3, BMPR1A
Genetic testing for prostate cancer risk is becoming more prevalent, particularly for those with a family history. Variants such as those found in the HOXB13 gene can indicate a higher chance of developing prostate cancer. Awareness and regular check-ups can lead to early detection, where treatment options are most effective and outcomes are generally positive.
Other genes associated with an increased risk of prostate cancer: BRCA1, BRCA2, MLH1, MSH2, MSH6, PMS2, EPCAM, TP53, ATM, HOXB13
Ovarian cancer is a hallmark cancer for HBOC (Hereditary Breast and Ovarian Cancer Syndrome). As many as 24% of ovarian cancers are hereditary. For women with such mutations, proactive management strategies like heightened surveillance, preventive surgeries and oral contraceptives may be considered. Research has shown taking an oral contraceptive for 5 years can reduce ovarian cancer risk by 50%.
Genes associated with ovarian cancer: BRCA1, BRCA2, MLH1, MSH2, MSH6, PMS2, EPCAM, RAD51C, RAD51D, STK11, PALB2, BRIP1
Endometrial cancer is a common gynecological cancer associated with Lynch Syndrome and other hereditary cancer mutations. Risk-reduction strategies include; maintaining a healthy diet and body weight, frequent exercise, avoiding smoking and limiting alcohol consumption.
Genes commonly associated with endometrial cancers: MLH1, MSH2, MSH6, PMS2, EPCAM TP53, PTEN, STK11, NTHL1
While often associated with environmental factors, melanoma and other skin cancers can also have a genetic component. Family history can suggest a genetic predisposition, prompting enhanced vigilance with skin checks and sun protection. By understanding the risks associated with hereditary skin cancers, you can take informed and impactful steps towards prevention.
Genes associated with hereditary skin cancer: BRCA1, BRCA2, MLH1, MSH2, MSH6, PMS2, EPCAM, TP53, PTEN, CDK4, CDKN2A, BAP1, FH, FLCN, MITF, TERT
Genetic syndromes, such as Peutz-Jeghers syndrome, can increase one's susceptibility to pancreatic cancer. Given the aggressive nature of this disease, genetic counseling and screening for at-risk individuals can aid in early detection and informed decision-making. Knowledge is your strongest ally in the fight against hereditary pancreatic cancer.
Common genes associated with Pancreatic Cancer: BRCA1, BRCA2, MLH1, MSH2, MSH6, PMS2, EPCAM, TP53, PALB2, ATM, CDKN2A, CDK4, STK11
Learn about hereditary cancer and its impact on families.
If you have a family history of cancer or meet specific criteria, consider genetic testing.
Share your knowledge with friends and family so they too can understand their risk.
Support policies and initiatives that promote early detection and prevention of hereditary cancers.
If you've tested positive, get involved in testing programs for specific genetic mutations.
The Hereditary Cancer Foundation offers a wide range of programs to support high-risk individuals and their families:
Your donation can make a tangible difference. By supporting our mission, you contribute to life-saving genetic testing, educational resources, and community support initiatives.
Together, we can empower individuals to take control of their health, improve their quality of life, and prevent hereditary cancers. Your support fuels our programs and helps us reach those who need it most.
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Thank you for your commitment to a future where hereditary cancers are understood, managed, and prevented.
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